Timing is listed in GMT and is approximate. Agenda is subject to change
Tuesday, 4 June 2024
12:30 – 16:00 (GMT) | Tuesday Workshop – requires separate ticket (€350) The School Of Pharmacy And Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland Overcoming The Challenge of Poorly Soluble Drugs This workshop delves into the complexities surrounding the formulation of poorly soluble drugs, a prevalent concern affecting a significant percentage of active pharmaceutical ingredients. Explore the scientific nuances of amorphous forms and their role in amorphous solid dispersions (ASDs), offering insights into enhanced solubility and dissolution. The workshop is broken down into three sections: Harnessing The Amorphous and Ionic Liquid Forms of APIs Predictive Modeling and Simulation Tools Process Development and Scale-Up of Spray Drying Instructors: Anne-Marie Healy, Professor of Pharmaceutics and Pharmaceutical Technology at Trinity College Dublin João Henriques, Director, Oral Drug Product Development, Hovione Sanjay Konagurthu, Senior Director, PDS Global Science and Technology, Thermo Fisher Scientific Moderator: Dr. Kevin J. Bittorf, PhD, (Principal Consultant, SCxCMC Solutions) Sponsored by: Hovione |
| 16:30 – 17:30 | Walking Tour of Dublin Free to all registered attendees Meeting point: Sylvie Kleinman will meet the group @ Trinity College Front Gate at 16:30 |
| 17:30 – 19:30 | Opening Reception Sponsored by: MEDELPHARM-KORSCH The Chelsea Drugstore, 25 South Great George’s Street, Dublin 2, D02 XY71, Ireland |
Wednesday, 5 June 2024
| 9:00 (GMT) | Welcome & Agenda Overview The School Of Pharmacy And Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland |
| Wednesday AM: Formulation & Analytical Considerations in Compression Chair: Susanne Florin Muschert, Associate Professor, Inserm U 1008 “Advanced Drug Delivery Systems” & University of Lille | |
| 9:05 | Keynote: James Elliott, Joint Head of Department of Materials Science and Metallurgy at University of Cambridge; Professor of Macromolecular Materials Science at University of Cambridge Introducing the Volume-interacting Level-Set Discrete Element Method (VLS-DEM) for Simulating Particles with Complex Shapes |
| 9:50 | Artur Saramago, Scientist, Oral Drug Product Development, Hovione Direct scale-up of a dry granulation process using a material lean approach at lab-scale |
| 10:15 | BREAK Sponsored by: Crystal Pharmatech |
| 10:35 | Danny (Dingeman) van der Haven, PhD Student Simulating Powder Compaction Single-particle characterization of powders for direct use in DEM simulations |
| 11:15 | Moritz Rosch, Process Specialist, KORSCH AG Single Step Scale up from Compaction Simulator to Rotary Press |
| 11:30 | Stefan Klinken, Pharmacist, PhD Student, University of Düsseldorf Multivariate considerations on the trinity of compression |
| 12:00 | LUNCH Sponsored by: ThermoFisher |
| Wednesday PM: Linking Particle Properties to Tableting Performance Chair: Kendal Pitt, FRPharmS AFIChemE FAPS PhD. Pharmaceutical Consultant | |
| 13:05 (GMT) | Keynote: Daniel Markl CMAC, Professor in Pharmaceutical Product Engineering at University of Strathclyde A Self-optimised Tableting DataFactory: Accelerating Process and Formulation Development |
| 13:50 | Zoe Chu, EngD Student, AstraZeneca Comparison of Powder Surface Energy Measurement Methods |
| 14:15 | Issa Munu, Process Engineer, GSK/Birmingham Predicting granule and tablet properties using in-line measurements and evolutionary equation discovery |
| 14:40 | BREAK Sponsored by: Crystal Pharmatech |
| 15:00 | Kellie Sluga, Scientist at Genentech The Effects of Nano-Silica Dry Coating on the Properties of Die-Compacted Active Pharmaceuticals |
| 15:25 | Rahul Haware, Director of Scientific Support and New Business Development at Natoli Scientific Punch Geometries Impacts Evaluation on Tablet Capping with Newly Proposed Capping Index |
| 15:50 | Filip Francqui, Managing Director at Granutools Understanding the relation between permeability and packing fraction to improve tablet manufacturing |
| 16:15 | Phuong Bui, PhD Candidate at Drexel University College of Engineering Phase Transformation Mapping under Tablet Compaction using Rapid Measurement and Analysis from Backscattering Raman Spectroscopy |
| 16:30 | Posters & Networking Reception Sponsored by: Huxley Bertram Atrium @ The School Of Pharmacy And Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland |
| 18:00 – 21:00 | CSF Dinner Sponsored by: Merlin Location: The Market Bar, 14a Fade Street, Dublin D02 A368, Ireland |
Thursday, 6 June 2024
| Thursday AM: The Science and Application of Compaction Simulation Chair: Zelalem Ayenew Worku, PhD, Senior Scientist, Novo Nordisk, Formulation and Drug Product Development | |
| 9:05 (GMT) | Keynote: Abina Crean, Professor of Pharmaceutics, School of Pharmacy, University College Cork Formulation Design Considerations for Robust Pharmaceutical Compaction Processes |
| 9:50 | Yusuke Imayoshi, PhD student, Osaka Metropolitan University Elucidation of capping mechanism during high-speed tableting process using FEM simulation based on the fracture mechanics |
| 10:15 | BREAK Sponsored by: Crystal Pharmatech |
| 10:35 | Antonios Zavaliangos, A. W. Grosvenor Professor of Materials Science and Engineering at Drexel University Recent Developments in Detecting and Understanding Sticking |
| 11:05 | Moritz Anuschek, Industrial PHD Student, Novo Nordisk In-line monitoring of a lab-scale direct compression process with terahertz time- domain spectroscopy as a process analyser: simultaneous assessment of tablet height and mass |
| 11:30 | Shuji Ohsaki, Osaka Metropolitan University DEM analysis of compression process with the elastoplastic particles |
| 12:00 | LUNCH Sponsored by: ThermoFisher |
| Thursday PM: Practical Applications Chair: Elaine H. Stone, Consultant and Director, Stonepharma Ltd | |
| 13:20 (GMT) | Keynote: Gavin Reynolds, Senior Principal Scientist in Process Engineering and Digital, AstraZeneca Towards virtual formulation design of pharmaceutical tablets |
| 14:05 | Johny Bertels, Senior Scientist – Oral Solids Development at Johnson & Johnson Innovative Medicine Tableting: A shifting paradigm from art to science to AI |
| 14:30 | Charlotte Cartwright, Compaction Scientist, Merlin Powder Characterisation Case studies: Compression of disintegrants and exploring temperature of die effects. |
| 14:55 | BREAK Sponsored by: Crystal Pharmatech |
| 15:15 | Peyman Aminpour, Materials Scientist, Thermo Fisher Scientific Integrating Compaction Simulation for Accelerated Drug Product Development: Case Studies in Mini-Tablets and Tablet Technology Transfer |
| 15:40 | Vincent Mazel, Professor, Université de Bordeaux Tensile strength of pharmaceutical tablets: comparison of test configurations |
| 16:15 | Thursday’s Closing Remarks |
| 17:00 | Networking Reception Sponsored by: SCxCMC (location to be announced that afternoon) |
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