Agenda

Timing is approximate, Agenda is subject to change

Tuesday, 4 June 2024

12:30 – 4:00 PM
Tuesday Workshop – requires separate ticket (€350 – additional discount through 1 May)
Overcoming The Challenge of Poorly Soluble Drugs
This workshop delves into the complexities surrounding the formulation of poorly soluble drugs, a prevalent concern affecting a significant percentage of active pharmaceutical ingredients. Explore the scientific nuances of amorphous forms and their role in amorphous solid dispersions (ASDs), offering insights into enhanced solubility and dissolution. The workshop is broken down into three sections:
Harnessing The Amorphous and Ionic Liquid Forms of APIs
Predictive Modeling and Simulation Tools
Process Development and Scale-Up of Spray Drying

Instructors:
Anne-Marie Healy, Professor of Pharmaceutics and Pharmaceutical Technology at Trinity College Dublin
Joao Henriques, Director, Oral Drug Product Development, Hovione
Sanjay Konagurthu, Senior Director, PDS Global Science and Technology, Thermo Fisher Scientific

Moderator:
Dr. Kevin J. Bittorf, PhD, (Principal Consultant, SCxCMC Solutions)
4:30 PMWalking Tour of Dublin
Free to all registered attendees
5:00 PM – 7:00 PM (GMT) Opening Reception
Location To Be Announced

Wednesday, 5 June 2024

9:00 AM (GMT) Welcome & Agenda Overview
Wednesday AM: Formulation & Analytical Considerations in Compression
Chair: Susanne Florin Muschert, Associate Professor, Inserm U 1008 “Advanced Drug Delivery Systems” & University of Lille
9:05 AM (GMT)Keynote: James Elliott, Joint Head of Department of Materials Science and Metallurgy at University of Cambridge; Professor of Macromolecular Materials Science at University of Cambridge
Introducing the Volume-interacting Level-Set Discrete Element Method (VLS-DEM) for Simulating Particles with Complex Shapes
9:50 AMArtur Saramago, Scientist, Oral Drug Product Development, Hovione
Direct scale-up of a dry granulation process using a material lean approach at lab-scale
10:15 AMBREAK
10:35 AMDanny (Dingeman) van der Haven, PhD Student Simulating Powder Compaction
Single-particle characterization of powders for direct use in DEM simulations
11:00 AMMoritz Rosch, Process Specialist, KORSCH AG
Single Step Scale up from Compaction Simulator to Rotary Press
11:30 AMStefan Klinken, Pharmacist, PhD Student, University of Düsseldorf
Considerations on the trinity of compression in terms of formulation development
12:00 PMLUNCH
Wednesday PM: Linking Particle Properties to Tableting Performance
Chair: Kendal Pitt, FRPharmS AFIChemE FAPS PhD. Pharmaceutical Consultant
1:05 PM (GMT)Keynote: Daniel Markl CMAC, Reader in Pharmaceutical Product Engineering at University of Strathclyde
A Self-optimised Tableting DataFactory: Accelerating Process and Formulation Development
1:50 PMZoe Chu, EngD Student, AstraZeneca
Comparison of Powder Surface Energy Measurement Methods
2:15 PMIssa Munu, Engineering Doctorate Candidate, University of Birmingham and GSK
2:40 PMBREAK
3:00 PMKellie Sluga, Scientist at Genentech
The Effects of Nano-Silica Dry Coating on the Properties of Die-Compacted Active Pharmaceuticals
3:25 PMRahul Haware, Director of Scientific Support and New Business Development at Natoli Scientific
Punch Geometries Impacts Evaluation on Tablet Capping with Newly Proposed Capping Index
3:50 PMMarco Lupo, Particle Scientist, Granutools, Chemical Engineer & PhD in Chemical Engineering
Understanding the relation between permeability and packing fraction to improve tablet manufacturing
4:15 PMPhuong Bui, PhD Candidate at Drexel University College of Engineering
Phase Transformation Mapping under Tablet Compaction using Rapid Measurement and Analysis from Backscattering Raman Spectroscopy 
4:35 PMPosters & Networking Reception
6:00 PM – 9:00 PMCSF Dinner

Thursday, 6 June 2024

Thursday AM: The Science and Application of Compaction Simulation
Chair: Zalalem Worku, Senior Scientist, Alkermes, Formulation and Drug Product Development
9:05 AM (GMT)
Keynote: Abina Crean, Professor of Pharmaceutics, School of Pharmacy, University College Cork
Formulation Design Considerations for Robust Pharmaceutical Compaction Processes
9:50 AMAmrit Paudel, Deputy Scientific Director, RCPE GmbH & Associate Professor, Graz University of Technology
Crystal to Compact: multiscale insight into compaction of pharmaceuticals
10:15 AMBREAK
11:00 AMMarcus O’Mahony, Senior Research Fellow in Pharma Manufacturing, PMTC, University of Limerick
Impact of temperature and humidity on compaction properties
11:25 AMAntonios Zavaliangos, A. W. Grosvenor Professor of Materials Science and Engineering at Drexel University
Recent Developments in Detecting and Understanding Sticking
12:30 AMYusuke Imayohsi, Professor at Osaka Metropolitan University
Elucidation of capping mechanism during high-speed tableting process using FEM simulation based on the fracture mechanics
12:15 PMLUNCH
Thursday PM: Practical Applications
Chair: Elaine H. Stone, Consultant and Director, Stonepharma Ltd
1:15 PMKeynote: Gavin Reynolds, Senior Principal Scientist in Process Engineering and Digital, AstraZeneca
Towards virtual formulation design of pharmaceutical tablets
2:05 PMJohny Bertels, Senior Scientist – Oral Solids Development at Johnson & Johnson Innovative Medicine
Tableting: A shifting paradigm from art to science to AI
2:30 PMCharlotte Cartwright, Compaction Scientist, Merlin Powder Characterisation
Case studies: Compression of disintegrants and exploring temperature of die effects.
2:55 PMBREAK
3:15 PMPeyman Aminpour, Materials Scientist, Thermo Fisher Scientific 
Integrating Compaction Simulation for Accelerated Drug Product Development: Case Studies in Mini-Tablets and Tablet Technology Transfer
3:40 PMVincent Mazel, Professor, Université de Bordeaux
Tensile strength of pharmaceutical tablets: comparison of test configurations
4:15 PMThursday’s Closing Remarks